Tuesday, August 6, 2019
Pizza Hut Case Study Essay Example for Free
Pizza Hut Case Study Essay Create awareness for the introduction of the new pizza crust ââ¬ËFreshizzaââ¬â¢, highlighting FRESHNESS of the dough as a key ingredient for a perfect pizza. Situation Analysis Each Pizza Hut restaurant prepares fresh dough several times a day on premise, unlike competing brands whose stores receive crusts from a few central commissaries making the dough older by 1- 2 days. This fact had not been leveraged by Pizza Hut in the past. In the course of product development, Pizza Hut had commissioned research to evaluate the proposition of ââ¬ËFreshââ¬â¢ among consumer focus groups. The key findings here revealed that ââ¬ËFreshnessââ¬â¢ in the context of Indian bread (chappatiââ¬â¢s) implied kneading fresh dough daily. Consumers preferred chappatiââ¬â¢s made from freshly kneaded dough as they were softer and tastier than those made from two day old dough. This was unlike the perception on pizzaââ¬â¢s where ââ¬ËFreshnessââ¬â¢ was only understood as a piping hot pizza. Strategy The PR programme decided to use both the insights gained from the commissioned research, to present an all new pizza crust and focus on leveraging editorial opportunities to create awareness for freshness and differentiate the product on taste. In order to add credibility to product claims and influence media on the freshness of the product, PR Pundit considered it vital to get a leading food critique to endorse the product. Through dialogue and product sampling, the PR programme earned the support of Indiaââ¬â¢s leading food writer Rashmi Uday Singh, a lady whose name is synonymous with good food in India, to demonstrate the freshness of the Pizza Hutââ¬â¢s pizzas, through a unique ââ¬ËFreshizza Cookery Showââ¬â¢. The Challenge The challenge was to garner media support to create awareness for freshness and differentiate the product on taste. CASE STUDIES Execution Tactics. The PR Campaign was conceptualised to create a dramatic launch to highlight the freshness of the product, while subtly suggesting that the competitionââ¬â¢s product is not so fresh. The PR Plan rolled out with a cookery show and food sampling at New Delhiââ¬â¢s oldest Pizza Hut, which received nationwide media coverage. The programme was extended to the keenly competitive markets of Chennai, Bangalore and Mumbai. In Chennai and Bangalore a photo call was created with the in-store presence of local celebrities to launch Freshizza, while senior management addressed the media on the process followed at each restaurant to prepare fresh dough for pizzaââ¬â¢s. The Mumbai launch was timed to coincide with the introduction of the television commercial (TVC) featuring one of Indiaââ¬â¢s top model ââ¬â Malaika Arora Khan. Consumer media was invited for a preview of the TVC and to the restructured cookery show ââ¬ËGet Fresh with Malaikaââ¬â¢ featuring the top model and Rashmi Uday Singh at a local Pizza Hut. This resulted in yet another nation wide photo opportunity. In Kolkata and Pune, consumer and city press were invited to sample the new crust, while a press release with attractive product pictures was issued in Hyderabad and Chandigarh. HINDUSTAN TIMES ECONOMIC TIMES CASE STUDIES DIVYA BHASKAR The ââ¬ËFreshizza Cookery Showââ¬â¢ was fashioned to demonstrate the freshness of the pizza crusts from Pizza Hut in the form of a cookery show. The delightful repartee of actor Zayed Khan (Bollywood celebrity and brand ambassador of Pizza Hut) and food writer Rashmi Uday Singh was appreciated for its uniqueness and provided a live and interactive demonstration of the dough preparation process ââ¬â from the blending stage to the final pizza making for the media. The sight of the duo rolling out fresh pizza crusts made for a perfect photo opportunity. Freshly baked Freshizzaââ¬â¢s were served to the media for sampling In Mumbai too, the entire dough making process was recreated with the new face of the Freshizza campaign -Malaika Arora Khan paired with food writer Rashmi Uday Singh on the ââ¬ËGet Fresh with Malaika Showââ¬â¢. The launch was followed up by special Freshizza deliveries to key media offices to ensure broadest possible reach. Results and Impact. The launch events at the four major cities of the country received an enthusiastic response from nearly 150 journalists. The photo opportunity made it possible for product and brand to be carried across all major print, electronic and online media in India. In less than two months of the launch, one out of every four customers at Pizza Hut had tried out Freshizza, i. e. almost half a million customers have already sampled the product and the growth of sales grew by about 12ââ¬â15 per cent per restaurant.
Monday, August 5, 2019
NSAID Non-steroidal anti-inflammatory drugs
NSAID Non-steroidal anti-inflammatory drugs 1. Introduction 1.1 Ibuprofen, a Non-steroidal Anti-inflammatory Drug (NSAID) Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used and therapeutically effective groups of drugs in the medicinal field. They suppress inflammation in a similar way as steroids. They are also better than steroids in such a way that they cause less side effects of sedation, addiction and respiratory depression. NSAIDs act by inhibiting cyclooxygenase (COX) enzymes, COX-1 and COX-2. This type of inhibition results in reduced productions of precursors such as thromboxane, prostaglandin and leukotriene that are involved in the inflammatory pathways. NSAIDs are poorly water-soluble drugs (Hassan et al., 2009). Often, they are microencapsulated using the emulsion solvent diffusion method (Leo et al., 2000) to modify and retard drug release from pharmaceutical dosage form. Further, encapsulation of NSAIDs into polymeric nanoparticles, followed by their encapsulation into polymeric microparticles has proved to reduce the release rate and suppress the undesired initial burst. For instance, Ibuprofen-loaded PCL (Poly-epsilon-caprolactone) nanoparticles inside ethylcellulose/Eudragit RS polymeric microparticles was successfully encapsulated, which effectively exhibited a control of both the release rate and burst effect (Hassan et al., 2009; Socha et al., 2007). Ibuprofen, an NSAID, was selected as the model drug in this study. The low solubility (0.03-2.5mg/ml) (Khang et al., 2007) and short plasma half-life of approximately 2 hours of Ibuprofen makes it an ideal choice to prepare a controlled release dosage form. Ibuprofen is commonly used to relieve the symptoms of mild and moderate pain and inflammation in conditions such as migraine, dental pain, dysmennorhea, headaches, back pain, muscular pain, rheumatic pain, cold and flu symptoms. Also, it is used to treat chronic diseases such as rheumatoid arthritis in which a controlled release dosage form is desired for symptom relief (Leo et al., 2000). Although parenteral Ibuprofen formulation has been produced recently, there is no controlled release dosage form available in the pharmaceutical market. Considering that Ibuprofen is a anti-inflammatory agent used widely, this study of preparation of a biodegradable and controlled release parenteral Ibuprofen dosage form, based on nanoparticles will definitely of great interest. For example, the intraarticular administration of Ibuprofen would offer an effective management of chronic rheumatoid arthritis. Also, it will serve an alternative to corticosteroid administration to avoid the devastating side effects (Hassan et al., 2009; Fernandez-Carballido et al., 2004). Besides, two types of parenteral formulations of Ibuprofen are now available in the pharmaceutical market. One of them is Pedea which is used for the therapy of ductus arteriosus in preterm newborns (Hassan et al., 2009, Aranda and Thomas, 2006). Its use in human pre-mature newborns was also demonstrated to be able to improve the cerebral blood flow regulation and potentially offer some degree of neuroprotection (Aranda and Thomas, 2006). It is a normal aqueous solution dosage form which is injected into the bloodstream, allowing fast therapeutic activity. Another parenteral Ibuprofen formulation is marketed by Cumberland Pharmaceuticals recentlyââ¬â the injectable ibuprofen formulation named Caldolor which is used for the treatment of pain and fever. Caldolor has also proved to have the advantage of reducing pain and fever significantly within 30 minutes. Although rapid attainment of therapeutic effect can be achieved, the short plasma half-life of Ibuprofen would have resulted in frequent administration in order to maintain plasma therapeutic levels. For instance Caldolor needs to be administered intravenously every 6 hours in order to maintain efficient plasma therapeutic levels. Therefore, controlled drug delivery systems would be a better yet excellent alternative to multiple injections. And, in such case, polymeric nanoparticles will be the best candidate for parenteral drug delivery. This polymeric nanoparticulate drug delivery system would be potentially used to increase bioavailability, provide prolonged therapeutic plasma levels and reduce administration frequency. 1.2 Controlled Drug Delivery and Drug Targetting To deliver drugs from the administration site to the target site, a delivery system is needed as drugs could not deliver by themselves (Davis and Illum, 1998; Bala et al., 2004). An ideal drug delivery system will possess both the properties of targeting and controlling the drug release (Thassu et al., 2007). Targeting ensures high effectiveness of the drug and at the same time reduces the possible devastating side effects that may be experienced. This is particularly beneficial when dealing with drugs for instance, drugs used in cancer therapy to ensure that only affected cancer cells but not healthy cells are killed (Brannon-Peppas and Blanchette, 2004). The reduction of side effects can also be attained through controlled release dosing systems. This study will focus on the parenteral controlled-release dosage forms. 1.2.1 Rationale for Parenteral Controlled-release Drug Delivery Parenteral controlled-release dosage forms have been proved to be useful for treating disease (Kydonieus, 1992). However, there is no single controlled-release technology that has proved to be effective in treating disease because of the diversity of drug properties, dosing levels, treatment durations as well as patient acceptability and cost. Therefore, an excellent controlled release technology is needed to be selected for each drug and associated disease treatment. The distribution of drug in the body after parenteral administration well depends entirely on the physicochemical properties of the drug. Conventional drug delivery is typically illustrated by drug administered via bolus injection, in which the most of the therapeutic agents in the drug are released immediately after the administration, causing a rapid increase of the plasma drug concentration levels (Uhrich et al., 1999). Drug concentration is then seen to fluctuate between the side effect level and the minimum therapeutic level, resulting in alternate periods of toxicity and ineffectiveness (Stevanovic and Uskokovic, 2009). As a consequence, higher dosage drug is needed to be administered repeatedly to maintain the therapeutic drug concentration at steady state level. Problems, hence, arise as multiple injections are not favoured by most patients. Therefore, in order to improve efficacy, patient compliance and convenience, a controlled-release parenteral dosage forms that can last for longer period of time after a single administration will be more beneficial. This controlled release over an extended time is also of great benefits for drugs that are rapidly metabolized and eliminated from the body after administration. This is because controlled release maintains drug concentration at steady state level for a sufficient duration at the target sites, where the rate of drug release is equivalent to the rate of drug elimination, thus keeping the drug concentration within the ideal therapeutic window as well as avoiding substantial fluctuations. As a result, frequent injections can be avoided. 1.3 Nanotechnology for Controlled Drug Delivery In the endeavour to design a parenteral controlled release dosage form, a number of drug delivery systems, such as emulsions, micelles, liposomes and nanoparticles have been developed (Kydonieus, 1992; Hassan et al., 2009). In fact, injectable, biodegradable nanosphere products are the most recent technology developed for parenteral controlled-release dosage forms. This termed nanoparticulate drug delivery system, which comprises of colloidal particles of nanosize range, provides a suitable mean of delivering not only small molecular weight drugs but also macromolecules such as hormones, proteins, peptides and nucleic acids (Bala et al., 2004; Panyam and Labhasetwar, 2003). Furthermore, the nanoparticulate drug delivery system evidences the successful development of the nanotechnology. The prefix ââ¬Å"nanoâ⬠is derived from the Greek word dwarf (Thassu et al., 2007). One nanometer (nm) is equivalent to one-billionth of a meter. Materials in the nanometer size range can have substantial properties compared with the same materials at a larger size, for instance materials in the micrometer size range (Hans and Lowman, 2002). The term ââ¬Å"nanotechnologyâ⬠was coined in 1974 by Norio Taniguchi, a professor of the Tokyo Science University, Japan to describe materials in nanometers (Kydonieu, 1992). In recent years, nanotechnology has gained much attention that there has been an increasing investment trend from governments and private sector business in many parts of the world to expand research in nanoscale science and technology. Generally, nanotechnology means any technology performed on a nanoscale that involves both science and engineering (Bhushan, 2004). It encompasses the manufacture and application of biological, chemical and physical systems at scales that range from individual atoms or molecules to nanoscale dimensions. Also, it integrates the resulting nanostructures into larger systems (Bhushan, 2004). Controlled drug delivery nanotechnology has become one of the most advancing areas of science that contributes to human health care. This field of pharmaceutical technology has grown and expanded rapidly these days. And it is believed that such delivery system will definitely bring abundant advantages compared to conventional drug delivery system. 1.4 Natural and Synthetic Polymers in Pharmaceutical Systems Polymers are high molecular weight substances that are made up of repeating monomer units. In order to develop a successful nanoparticulate delivery system, it is essentially important to select an appropriate polymeric matrix. Polymers nanospheres employed to deliver drugs in a sustained release manner can be either biodegradable or non-biodegradable (Uhrich et al., 1999). The controlled release can be achieved by combining the biodegradable polymer with a drug so that the active agent is released from the system in a predesigned way. Despite the fact that controlled drug delivery has various advantages, the possible drawbacks cannot be overlooked: the undesirable by-products from degradation, potential toxicity or non-biocompatibility of the materials used, any surgery involved to remove or implant the system, the likehood of patient discomfort from the delivery device, and the higher cost involved compared with traditional pharmaceutical formulations (Stevanovic and Uskokovic, 200 9; Brannon-Peppas, 1997). Several polymers, including both natural and synthetic polymers have been investigated for formulating biodegradable polymeric nanoparticles. These include polylactide (PLA), polycaprolactone (PCL) and poly(lactide-co-glycolide) (PLGA), which are biodegradable and biocompatible. Among these polymers, PLGA is the most commonly used due to its biodegradability, biocompatibility as well as flexible degradation kinetics (Sahana et al., 2007). In fact, PLGA has been approved by FDA (Food and Drug Administration) for a number of clinical applications (Bhardwaj et al., 2005) such as synthetic resorbable sutures, surgical clips and other surgical implants (Kydonieus, 2005). 1.4.1 Poly(lactide-co-glycolide) (PLGA) as Polymers PLGA is a copolymer of PLA and PGA. It is synthesised by co-polymerisation of two different monomers, the cyclic dimmers of glycolic acid and lactic acid. During polymerisation, successive monomers of both glycolic and lactic acid are linked together by ester bonds, producing a linear polyester of PLGA. Different forms of PLGA can, thus, be yielded by altering the mixing ratio of lactide to glycolide used in the polymerisation process. A basic insight of physicochemical and biological properties of the PLGA polymer is vital as it allows the study of the mechanism and rate of drug release from the nanoshperes. PLGA degrades in vivo by hydrolytic cleavage of the ester linkage in the presence of water (Bala et al., 2004; Stevanovic and Uskokovic, 2009). However, the degradation process of polymers is affected by a number of factors. The polymer nature (polydispersity and copolymer composition), the degree of crystallinity, the glass transition temperature of the polymer, organic solvents, type and concentration of stabiliser used are all the common factors (Bala et al., 2004). The degradation profile of nanoparticulate systems, on the other hand, relies on the hydrophilicity of the polymer. The more hydrophilic the polymer, the higher its rate of degradation (Bala et al., 2004; Stevanovic and Uskokovic, 2009). In fact, the hydrophilicity of the polymer is determined by the crystalline to armorphous ratio, that is consecutively affected by the composition of the copolymer (Bala et al., 2004). Owing to the fact that lactide is more hydrophobic than glycolide, PLGA copolymers with high content of lactide units will be less hydrophilic, thus experiencing slower degradation process. For this reason, the rate of degradation and release profile of PLGA can be modified easily by varying the ratio of lactide to glycolide (Sahana et al., 2007). It is noted that PLGA copolymer with composition of 50:50 ratio shows the fastest degradability rate about 1-2 months in both in vitro and in vivo conditions (Stevanovic and Uskokovic, 2009; Nair and Laurencin, 2007). Extensi ve investigations were then carried out on different forms of PLGA by changing the ratio of lactide to glycolide. The results showed that the PLGA copolymers of 65:35, 77:25, and 88:15 lactide/glycolide ratios have progressively longer in vivo degradation times, with the 88:15 one lasting about 5-6 months in vivo (Bala et al., 2004; Jain, 2000). During the preparation of PLGA loaded nanoparticles in this study, lactide-rich copolymers will be of great interest in order to formulate a nanosphere with controlled release properties. PLGA is undoubtedly the ideal choice of polymer selected to be used in designing a controlled release nanoparcticulate delivery system. Because of its biodegradability, no surgical procedures are needed to remove the system when the drugs are depleted. Besides, it is degraded in vivo, by random, nonenzymatic, hydrolytic cleavage of ester linkages to toxicologically safe by-products (the original monomers- lactic and glycolic acid) that are either excreted renally or elimininated as carbon dioxide gas and water via Krebs cycle (Bala et al., 2004; Galindo-Rodriguez et al., 2005). Furthermore, PLGA has a glass transition temperature above physiological temperature (45-55à °C) that provides it adequate strength to be formulated as a successful controlled drug delivery system (Bala et al., 2004). Because PLGA have proved to be biocompatible and to have extensive toxicological documentation, their approvals for use in fabricating nanospheres will be less costly and more straightforward th an approvals of new polymers for fabrication in the pharmaceutical industry. For this reason, PLGA copolymers are selected as the colloidal carrier for parenteral controlled-release dosage forms in this study. 1.4.2 Therapeutic Uses of PLGA Polymers in Contemporary Clinical Formulations The use of the PLGA polymer for the development of new parenteral controlled drug delivery dosage forms appears to be very promising. Nanospheres with various release patterns can be prepared by altering the polymer species, molecular weight or monomer mixing ratio. FDA has approved PLGA for a number of medical applications. For instance, Lupron Depotà ®, a controlled release formulation for treatment of advanced prostate cancer, was the first PLGA product cleared by FDA (Bala et al., 2004). The effective dose this formulation, which contains leuprolide acetate encapsulated in biodegradable microspheres of 75:25 lactide/glycolide polymer, was reduced 1/4 ââ¬â 1/8 of that required in the conventional drug formulation (Sahana et al., 2007). Another successful development of controlled drug delivery systems includes anticancer drug, Doxorubicin formulated into PLGA nanoparticles, that exhibited controlled release over 1 month (Bala et al., 2004). In the following research work, Ibu profen loaded PLGA nanoparticles are intended to be prepared with a view to possess the identical desired controlled release properties. 1.4.3 Preparation of PLGA loaded nanoparticles Several approaches have been proposed for the preparation of PLGA nanoparticles. However, the choice of preparation method well depends on the type of the polymer and drug used, the intended use as well as the duration of the treatment. The standard procedures of emulsion-diffusion evaporation, salting-out and nanoprecipitation method are all widely used to prepare PLGA particles in the nanosize range. The first step of these methods often involves emulsification of a solution of drug in a solution of organic polymer (Stevanovic and Uskokovic, 2009). The dispersion formed is then processed in accordance with one of the aforestated methods. During both emulsion-diffusion evaporation and salting out approaches, the polymer PLGA is dissolved in an organic solvent such as chlorinated solvent, dichloromethane and chloroform, tetrahydrofuran, acetone or ethyl acetate. The mixed organic solution of both polymer and drug is later mixed with an aqueous solution containing both stabiliser and emulsifying agents. The emulsion formed is then exposed to a high-energy source for example an ultrasonic device, homogenizer or colloid mill to form a stable oil-in-water (o/w) emulsion. The organic solvent is later evaporated under reduced pressure or continuous stirring, resulting in the formation of fine dispersion of nanoparticles containing therapeutic drugs. Factors such as homogeniser stirring rate, concentration of polymer, presence of surfactants and stabilisers will influence the size of the particles formed (Bala et al., 2004; Stevanovic and Uskokovic, 2009). Therefore, it is important to standardise these parameters in order to produce particles of desired size range. The nanoprecipitation method, on the other hand, is based on the interfacial deposition of a polymer following displacement of a semi-polar solvent miscible with water from a lipophilic solution (Bala et al., 2004; Govender et al., 1999). The PLGA polymer and drug are then dissolved in a semi-polar water-miscible solvent, either acetonitrile or ethanol, forming the organic phase. The organic phase is then mixed with an aqueous solution containing stabiliser and stirred magnetically at room temperature to allow rapid solvent evaporation. The nanoparticles are finally purified using ultracentrifugation, ultrafiltration, gas chromatography, dialysis procedures to remove stabiliser residues or any free drug. This purification process must be carefully carried out to avoid any loss of biologically active ingredients. 1.5 Aims and Objectives Realising the benefits and importance of controlled drug release in clinical applications, the objective of the present study is to prepare and characterise Ibuprofen loaded PLGA nanoparticles for parenteral delivery, with a view to prolong the ibuprofen blood residence time after injection. The objective will be achieved by the following specific aims: 1. Preparation of Ibuprofen loaded PLGA nanoparticles. 2. Characterization of the nanoparticles for size, zeta potential, and entrapment efficiency. References Aranda JV, Thomas R, 2006. Systemic review: Intravenous Ibuprofen in preterm newborns. Elsevier: Seminar in Perinatology. Bala I, Hariharan S, Ravi Kumar MNV, 2004. PLGA nanoparticles in drug delivery: The State of the Art: Critical Review in Therapeutic Drug Carrier Systems. 21(5), 387-422. Bhardwaj V, Hariharan S, Bala I, Lamprecht A, Kumar N, Panchagnula R, Ravi Kumar MNV, 2005. Pharmaceutical aspects of polymeric nanoparticles for oral delivery. Journal of Biomedical Nanotechnology. 1, 1-23. Bhushan B, editor, 2004. Springer handbook of nanotechnology. New York: Springer. Brannon-Peppas L, Blanchette JO, 2004. Nanoparticle and targeted systems for cancer therapy. Advanced Drug Delivery Reviews. 56, 1649-1659. Brannon-Peppas L, 1997. Polymers in controlled drug delivery. Medical Plastics and Biomaterials Magazine. Davis SS, Illum L, 1998. Drug delivery systems for challenging molecules. International Journal of Pharmaceutics. 176, 1ââ¬â8. Fernandez-Carballido A, Herrero-Vanrell R, Molina-Martinez IT, Pastoriza P, 2004. Biodegradable ibuprofen-loaded PLGA microspheres for intraarticular administration. Effect of Labrafil addition on release in vitro. International Journal of Pharmaceutics. 279, 33-41. Govender T, Stolnik S, Garnett MC, Illum L, Davis SS, 1999. PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug. Journal of Control Release 1999. 57, 171ââ¬â185. Hans ML, Lowman AM, 2002. Biodegradable nanoparticles for drug delivery and targeting. Current Opinion in Solid State and Materials Science. 6, 319-327. Hassan AS, Sapin A, Lamprecht A, Emond E, Ghazouani FE, Maincent P, 2009. Research paper: Composite microparticles with in vivo reduction of the burst release effect. European Journal of Pharmaceutics and Biopharmaceutics. Jain RA, 2000. The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. Biomaterials. 21, 2475ââ¬â2490. Jiang BB, Hu L, Gao CY, Shen JC, 2005. Ibuprofen-loaded nanoparticles prepared by a co-precipitation method and their release properties. International Journal of Pharmaceutics. 304, 220-230. Khang G, ChanYang J, TaeKo J, SooPark J, SukKim M, Rhee JM, BangLee H, 2007. Preparation and characterisation of ibuprofen using self-emulsifying drug delivery system in vivo. Key Engineering Materials. 342-343, 541-544. Kydonieus A, editor, 1992. Treatise on controlled drug delivery. New York: Marcel Dekker, Inc. Leo E, Forni F, Bernabei MT, 2000. Surface drug removal from ibuprofen-loaded PLA microspheres. International Journal of Pharmaceutics. 196, 1ââ¬â9. Nair LS, Laurencin CT, 2007. Biodegradable polymer as biomaterials. Progress in Polymer Science. 32, 762-798. Panyam J, Labhasetwar V, 2003. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Advanced Drug Delivery Reviews. 55, 329ââ¬â347. Sahana DK, Mittal G, Bhardwaj V, Ravi Kumar MNV, 2007. PLGA nanoparticles for oral delivery of hydrophobic drugs: Influence of organise solvent on nanoparticles formation and release behaviour in vitro and in vivo using Estradiol as a model drug. Wiley InterScience. Socha M, Hasan AS, Lamprecht A, Ghazouani FE, Sapin A, Hoffman M, Maincent P, Ubrich N, 2007. Effect of the microencapsulation of nanoparticles on the reduction of burst release. International Journal of Pharmaceutics. 344, 53ââ¬â61. Stevanovic M, Uskokovic D, 2009. Poly(lactide-co-glycolide)-based Micro and Nanoparticles for the Controlled Drug Delivery of Vitamins. Current Nanoscience. 5, 00-00. Thassu D, Deleers M, Pathak Y, editors, 2007. Nanoparticulate drug delivery systems. Vol 166. New York: Drugs and the Pharmaceutical Sciences. Uhrich KE, Cannizzaro SM, Langer RS, Shakesheff KM, 1999. Polymeric systems for controlled drug release. Chemical Reviews. 99, 3181-3198.
Sunday, August 4, 2019
Exemplification Essay: Cruising Should be Banned -- Exemplification Ess
Most of us have enjoyed "cruising" sometime in our lives. For many, it was one of our favorite pastimes. If you lived in the "American Graffiti" era, it was the in thing of to do. I remember when cruising was a popular activity on Main Street in Mesa for many years, until it was banned a few years ago. Now the controversy is over whether to ban cruising on Central Avenue in Phoenix. City officials are trying to reroute the weekend riders to Washington and Jefferson streets. Although cruising may be enjoyable to quite a few teenagers, there is no positive purpose for it. The negative effects of cruising outweigh the reasons for it by far. Cruising should be banned altogether because cruisers have proven to be very loud, dangerous, and a contributor to our pollution problem. I have sympathy for those who live near Central Avenue. The weekends are very noisy in this vicinity. For example, some of the stereos blasting away could accommodate a rock concert. The base volume coming out of these speakers is felt in your heart as you drive along Central...
Saturday, August 3, 2019
Lord of the Flies Essay -- Analysis, WIlliam Golding
Lord of the Flies, by William Golding, is a story about a band of British boys that crash land on a deserted island, with no adults anywhere to be found. They are left to fend for themselves as order comes to an end and the island swallows them whole. Two key and complex symbols in this story are a conch shell and fire. The conch is a tool Ralph and Piggy, two boys on the island, find in the beginning of the story while searching for other boys that may have survived the crash. The fire is a way for the boys to stay ââ¬Å"warm and safeâ⬠while they are on the island. As the young British boys become more aware of the dangers on the island, the conch and fireââ¬â¢s physical and symbolic manifestations change as life on the island begins to fall apart. In the beginning, the conch symbolized a way of holding onto the boysââ¬â¢ school life. When the conch was blown and the powerful sound echoed throughout the island, Piggy claimed, ââ¬Å"I bet you can hear this for milesâ⬠(17). Just as Piggy said this, children started to appear among the palms in the forest. The conch that called them together portrayed the kidsââ¬â¢ school bell. It made most of them feel safe when they were confused about what was might happen to them. The conch also brought order to the boys on the island. ââ¬Å"Weââ¬â¢ll have rulesâ⬠ââ¬Å"Iââ¬â¢ll give the conch to the person next to me. He can hold it when heââ¬â¢s speaking.â⬠(33). Without adults they were forced to create rules for themselves because order would have to be kept on the island until they were saved. At their school order was everything and they wanted to keep that order and thought of safety. The conch gave them a feeling of home and hope of getting off the island. To increase their feeling of safety on the island the boys decided to... ...he difference between a pig or a human anymore. What did he use to kill a pig? Fire. And now, it was exactly what he was going to use for Ralph. They wanted to smoke him out and set the island on fire (197). The fire consumed the forest and darkness had taken over for good. The fire left nothing behind but the memory of what had happened on the island. The fire and the conch started out bright, full of life and gave the boys confidence and a feeling of home. As life falls apart on the island, the fire grows stronger and rich in color and the conch grows weaker and dull. When the conch breaks, society and any faith in order comes to an end. In the end, fire consumes everything and the hope for survival comes to a close. The complex concepts of fire and the conch changed along with the boysââ¬â¢ life on the island and in a way led them to their ultimate downfall.
Energy :: essays research papers
-à à à à à The pump found in the tropical oceans is responsible for the movement of air and the surface ocean over most of the globe. The energy source that drives this pump is solar radiation from the sun. -à à à à à The second pump is the deep ocean circulation which is also driven by the sun. -à à à à à The third pump is the heating of the earthââ¬â¢s interior by radioactive decay and radiation of heat causes plate tectonics and continents to move. This long term pump has ceased in Mars. -à à à à à The winds and ocean currents redistribute the energy received from the Sun -à à à à à Air moves from high pressure areas to low pressure areas horizontally due to horizontal differences in pressure. -à à à à à As a parcel of air warms up it becomes more buoyant and the air rises. Warmer air has less density. -à à à à à Pressure differences among air masses are typically related to the distribution of surface temperatures -à à à à à The radiation reaching the Earth is spread over larger and larger areas as we move from the equator to the poles. You get more light per unit area at the equator than at high latitudes. -à à à à à The incoming solar radiation varies with latitude and seasons, whereas the outgoing terrestrial radiation depends on the temperature at the surface and atmosphere. -à à à à à Primary causes for temperature distribution on earth are because itââ¬â¢s warmer at the equator and colder at higher latitudes. -à à à à à The solar radiation absorbed at the surface varies with cloud cover and atmospheric absorption. -à à à à à Heated air rises at the equator causing air to move towards the equator. This converging air makes up the intertropical convergence zone. -à à à à à Rising air cools which causes it to loose its water in the form of rain. -à à à à à Areas of rising air cause low pressures. -à à à à à The warmer stratosphere acts as a barrier to the rising warm air causing it to spread out and diverge. As the air diverges it becomes more and more cooler and it sinks at 30 degrees N/S of the equator (Hadley Cell) -à à à à à Most of the earthââ¬â¢s deserts are located at about 30 degrees N/S of the equator. Descending air causes an area of high pressure at this 30 degrees N/S -à à à à à Hadley Cell: the convergence occurring in the tropics and divergence some 30 degrees N/S of it is called the Hadley Cell. -à à à à à The Hadley Cell and the ITCZ are not continuous around the globe. -à à à à à The equatorward-moving cold air meets the warm air moving poleward from the subtropics producing a zone of steep temperature gradients called the polar front zone at approximately 60 degrees N/S latitude.
Friday, August 2, 2019
Examine the language Essay
A soliloquy is during a play when an actor will speak his/her thoughts out loud to the audience. The actor will usually stand-alone on stage but if another actor is on stage they will go on with what they are doing. The purpose of a soliloquy is to help the audience understand the imagery. Shakespeare used soliloquies for the audience due to them going to listen to a play instead of watching it as we do today. Throughout the play Shakespeareââ¬â¢s soliloquies are full of contrasting images. These images mostly are contrasting themes from the play, in this case Love which is Romeo & Julietââ¬â¢s love for each other, Hate between the families of Montagueââ¬â¢s & Capulet, Violence fighting between families, Young Ideas which is Romeo & Juliet want to marry for love and not suitors chosen by their parents, Traditional Values the arranged marriages. In the soliloquy beginning â⬠Well Juliet, I will lie with thee to-night. â⬠Romeo describes death. Romeo describes that he wants to join Juliet in death. The imagery created by Shakespeare is revolting during this soliloquy. There is a large contrast from the middle and near the end of the soliloquy. Romeo goes and bys poison from the apothecary. An apothecary is like a morgue. This image of death describes and implicates the theme of death running through the play. There is a large similarity between the soliloquy starting ââ¬Å"Well Juliet, I will lie with thee to-nightâ⬠and ââ¬Å"Villain and he be miles asunder. â⬠It is in ââ¬Å"Villain and he be miles asunderâ⬠Juliet show to her family that she is upset over the death of her cousin Tybalt due to Romeo killing him, but infact she is more upset due to Romeo being banished from Verona. And in ââ¬Å"Well Juliet, I will lie with thee to-nightâ⬠Romeo is very upset due to him thinking Juliet is dead. This is dramatic irony because the audience know that she is not dead. This Make it standout how important love is in the play. In the soliloquy ââ¬Å"My only love, sprung from my only hateâ⬠is a common soliloquy for the rhyming couplet. A rhyming couplet is when the last two words in each line rhyme. This Happen in this soliloquy. In this soliloquy Juliet says, ââ¬Å"My only love, sprung from my only hateâ⬠What she means is that Romeo is a Montague and she is a Capulet. There has been a grudge between the two families for years. Juliet means she loves a member of the Montague family, which is supposed to be her enemy. In most of the soliloquies there is a lot of reparation. One example is Juliet says before she drinks the friarââ¬â¢s potion, ââ¬Å"dash out my desperate brainsâ⬠and then Romeo talks of ââ¬Å"desperate menâ⬠. The reparation shows how desperate the situation is in their lives. In the last scene in of the play there are 2 touching soliloquies. The main one is from Romeo. He starts ââ¬Å"how oft when men are at the point of deathâ⬠He is talking about the meaning of death parting lovers in this soliloquy. The other is from Juliet saying about Romeo being taken from her. so she takes his dagger so she can join he love in heaven.
Thursday, August 1, 2019
Hannin Essay
The government must show accountability for public funds and a business can use its resources as it deems appropriate. 5. Role of the Budget ââ¬â Commercial itââ¬â¢s used for planning and control purposes, for government budgets carry the authority of law, preventing 1-3. Identify and briefly describe the three organizations that set standards for state and local governments, the federal government, and nongovernmental not-for-profit organizations. 1. GASB set the accounting and financial reporting standards for state and local government in the US. GASB also set accounting and financial reporting standards for governmentally related not for profit organizations. 2. FASB set standards for profit seeking business and for nongovernmental not for profit organizations. 3. FASAB set the accounting and financial for the federal government. 1-4. What is the definition of a government as agreed upon by the FASB and GASB? Public corporations and bodies corporate and politic are governmental organizations. Other organizations are governmental organizations if they have one or more of the following characteristics. . Popular election of officers or appointment (or approval) of a controlling majority of the members of the organizationââ¬â¢s governing body by officials of one or more state or local governments. 2. The potential for unilateral dissolution by a government with the net assets reverting to a government. 3. The power to enact and enforce a tax levy. 1-5. Describe the ââ¬Å"hierarchy of GAAPâ⬠for state and local governme nts, the federal government, and nongovernmental not-for-profit organizations. (See Illustration 1-2 come back to this) 1-8. GASB considers budgetary accounting and reporting to be important. List the principles outlined by GASB related to budgetary accounting and reporting. 1. An annual budget(s) should be adopted by every governmental unit. 2. The accounting system should provide the basis for appropriate budgetary control. 3. Comparisons should be included in the appropriate financial statements and schedules for governmental funds for which an annual budget has been adopted. 2-2. With regard to GASB rules for the financial reporting entity, answer the following: 1. Define the financial reporting entity. It is the primary government together with its component units. 2. Define and give an example of a primary government. Can be a state government, a general-purpose local government such as a city or county, or a special purpose government such as a school district. 3. Define and give an example of a component unit. Are legally separate organizations for which the elected officials of the primary government are financially accountable. 4. Define and describe the two methods of reporting the primary government and component units in the financial reporting entity. a. Primary Government -either appoints a voting majority of the governing body of the other organization or members of the primary governmentââ¬â¢s governing body hold a majority of the seats of the other organizationââ¬â¢s board. Second, the relationship meets one of the following two criteria: a. The other organization provides either a financial burden or benefit to the primary government. b. The primary government can impose its will on the other organization. b. Component units ââ¬â are legally separate organizations for which the elected officials of the primary government are financially accountable. In addition, a component unit can be an organization for which the nature and significance of its relationship with a primary government are such that exclusion would cause the reporting entityââ¬â¢s financial statements to be misleading or incomplete. 2-3. With regard to the Comprehensive Annual Financial Report (CAFR): 1. What are the three major sections? Introductory, Financial, and Statistical. 2. List the government-wide statements. Indicate the measurement focus and basis of accounting used for the government-wide statements. Basic Financial Statements Proprietary Funds Statements: Statement of Cash Flows. Governments use the accrual basis and the modified accrual basis of accounting. 3. List the governmental fund statements. i. General fund. This fund is used to account for general operations and activities not requiring the use of other funds. ii. Special revenue funds are required to account for the use of revenue earmarked by law for a particular purpose. State and federal fuel tax revenues require special revenue funds, because federal and state laws restrict these taxes to transportation uses. iii. Capital projects funds are used to account for the construction or acquisition of fixed assets[9], such as buildings, equipment and roads. Depending on its use, a fixed asset may instead be financed by a special revenue fund or a proprietary fund. iv. Debt service funds are used to account for money that will be used to pay the interest and principal of long-term debts. Bonds used by a government to finance major construction projects, to be paid by tax levies over a period of years, require a debt service fund to account for their repayment. v. Special assessment funds account for public infrastructure improvements financed by special levies against property holders. Sidewalk and alley repairs often rely on special assessments. 4. Indicate the measurement focus and basis of accounting used for the governmental fund statements. It usually rely on a modified accrual basis. 5. List the proprietary fund statements. vi. Internal service funds are used for operations serving other funds or departments within a government on a cost-reimbursement basis. A printing shop, which takes orders for booklets and forms from other offices and is reimbursed for the cost of each order, would be a suitable application for an internal service fund. vii. Enterprise funds are used for services provided to the public on a user charge basis, similar to the operation of a commercial enterprise. Water and sewage utilities are common examples of government enterprises. 5. Indicate the measurement focus and basis of accounting used for the proprietary fund statements. i. Proprietary funds, used for business-like activities, usually operate on an accrual basis. Governmental accountants sometimes refer to the accrual basis as ââ¬Å"full accrualâ⬠to distinguish it from modified accrual basis accounting. 6. List the fiduciary fund statements. Statement of Changes in Fiduciary Net Assets and Statement of Changes in Fiduciary Net Assets. 7. Describe the measurement focus and basis of accounting used for the fiduciary fund statements. The accounting basis applied to fiduciary funds depends upon the needs of a specific fund. If the trust involves a business-like operation, accrual basis accounting would be appropriate to show the fundââ¬â¢s profitability. Accrual basis is also appropriate for trust funds using interest and dividends from invested principle amounts to pay for supported programs, because the profitability of those investments would be important. 8. Outline the reports and schedules to be reported as required supplementary information. Come Back To 2-4. Describe the test for determining whether a governmental fund is a major fund. The General Fund is always considered a major fund. Other governmental funds are considered major when both of the following conditions exist: (a) total assets, liabilities, revenues, or expenditures of that individual governmental fund constitute 10 percent of the total for the governmental funds category, and (b) total assets, liabilities, revenues, or expenditures of that individual governmental or enterprise fund are 5 percent of the total of the governmental and enterprise categories, combined. 2-10. Not sure
Subscribe to:
Posts (Atom)